The Python AMS enclosure is HUGE. Workbench space is too valuable, so I chose to mount the enclosure on the wall, requiring a bottom exit for the AMS cable and PTFE tube. I edited the original (v1.03b) STL files to fill in the existing holes, add material to the bottom surface, place the 8 threaded holes, and moved the back dovetail forward about 6 cm so the lateral screw hole is accessible. In my version, only the two holes closest to the center are opened up to allow the AMS cable to pass through. This is because the AMS cable can bend on a reasonably tight radius. I suggest using the outer holes for PTFE tube(s) where you can achieve a large, smooth radius. Another design feature is that the holes are sufficiently spaced from the back edge so that the 14mm screw fittings can be inside the box.

Of course you'll need to drill holes in the bottom panel of the enclosure, but only for the through holes you'll actually use. I used a ¾" Forstner bit in a hand held drill, went slowly, and had zero difficulty. A quick google search will provide tons of advice how to drill through the acrylic panels.

Assembly & printing notes: I used the heated insert version, as I really don't enjoy screwing machine screws into plastic. Four walls should be used for the heated insert version, three walls for the default version. I used 3 long inserts (5.7 mm) for the bottom panel, and 11 short inserts (4 mm) for all the others.

You may notice the power supply in the bottom of the enclosure. It's powering a Rosahl micro dehumidifier, mounted using this remix: https://makerworld.com/en/models/743617#profileId-676279